Boronic acid, B-[3-(4-morpholinylmethyl)phenyl]-

Boronic acid, B-[3-(4-morpholinylmethyl)phenyl]- - Names and Identifiers

Name	[3-(Morpholin-4-ylmethyl)phenyl]boronic acid
Synonyms	[3-(4-MorpholinylMethyl)Phenyl]-Boronic Acid [3-(Morpholin-4-ylMethyl)phenyl]boronic acid [3-(Morpholin-4-ylmethyl)phenyl]boronic acid B-[3-(4-morpholinylmethyl)phenyl]Boronic acid Boronic Acid, [3-(4-Morpholinylmethyl)Phenyl]- Boronic acid, B-[3-(4-morpholinylmethyl)phenyl]- boronic acid, B-[3-(4-morpholinylmethyl)phenyl]- [3-(morpholin-4-ylmethyl)phenyl]boronic acid HCl Boronic acid, [3-(4-morpholinylmethyl)phenyl]- (9CI) [3-(Morpholin-4-ylmethyl)phenyl]boronic acid hydrochloride
CAS	397843-58-2
InChI	InChI=1/C11H16BNO3/c14-12(15)11-3-1-2-10(8-11)9-13-4-6-16-7-5-13/h1-3,8,14-15H,4-7,9H2

Boronic acid, B-[3-(4-morpholinylmethyl)phenyl]- - Physico-chemical Properties

Molecular Formula	C11H16BNO3
Molar Mass	221.06
Density	1.208g/cm³
Boling Point	394.611°C at 760 mmHg
Flash Point	192.454°C
Vapor Presure	0mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.57

Boronic acid, B-[3-(4-morpholinylmethyl)phenyl]- - Risk and Safety

Hazard Class

IRRITANT

Boronic acid, B-[3-(4-morpholinylmethyl)phenyl]- - Introduction

[3-(Morpholin-4-ylmethyl)phenyl]boronic acid is an organoboron compound with the formula C12H16BNO3.

The properties of the compound are as follows:
-Appearance: Colorless crystalline solid
-Melting point: approximately 140-145°C
-Solubility: Soluble in many organic solvents such as chloroform, dimethylformamide and ethanol

[3-(Morpholin-4-ylmethyl)phenyl] The main uses of boronic acid are:
-As a reagent in organic synthesis: It can be used in organic synthesis reactions such as borane reaction and Suzuki-Miyaura coupling reaction of aromatic hydrocarbons.
-As an intermediate: It can be used as an intermediate for the synthesis of drugs and pesticides, and has certain applications in the field of medicinal chemistry and pesticide chemistry.

There are two main methods for preparing [3-(Morpholin-4-ylmethyl)phenyl]boronic acid:
1. The synthesis of morpholine methylphenylboronic acid can be obtained by the reaction of phenylboronic acid and morpholine formaldehyde under acid catalysis. The specific reaction conditions will be optimized according to the specific needs of the laboratory.
2. It can also be prepared by reacting phenylboronic acid with morpholine in the presence of potassium carbonate to generate morpholine benzoborate, and then reacting with formaldehyde under acidic conditions to prepare [3-(Morpholin-4-ylmethyl)phenyl]boronic acid.

Regarding safety information,[3-(Morpholin-4-ylmethyl)phenyl]boronic acid is generally safe under proper use and storage. However, every chemical has potential risks, so it is necessary to follow proper laboratory procedures when using it, and pay attention to personal protective measures, such as wearing gloves and goggles. At the same time, store it in a dry, cool place, and away from dangerous substances such as open flames and oxidants. If inhalation or skin contact occurs, wash immediately and seek medical help.

Last Update：2024-04-09 21:11:58